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52-Week Top Gaining U.S. stocks

Track U.S. stocks with the strongest price gains over the past 52 weeks on MEXC. Stocks are ranked by their 52-week percentage change to highlight leading one-year performers.

52-Week Top Gaining U.S. stocks

Market Overview

U.S. stocks are broadly lower today, with the Dow Jones down ⁦2.62%⁩, the S&P 500 down ⁦3.45%⁩, and the Nasdaq Composite down ⁦4.65%⁩. Market breadth is negative, with 4,530 stocks declining versus 585 advancing, pointing to a broadly bearish bias.

Dow Jones
51,960.1
Change
-1,396.02-2.62%
S&P 500
7,423.63
Change
-264.99-3.45%
Nasdaq Composite
24,540.006
Change
-1,196.507-4.65%
24H Gainers
585
24H Losers
4,530

52 Week Gainers

#Stock52 Week Range
4551Gaxos.ai Inc.GXAI$0.37-16.91%510.30K$4.12M$0.35 - $2.630.00%
4552Tenaya Therapeutics, Inc.TNYA$0.34-7.81%3.89M$77.50M$0.34 - $1.560.00%
4553Caring Brands, Inc.CABR$0.75-6.67%132.51K$10.89M$0.71 - $4.390.00%
4554OneMedNet Corp.ONMD$4.28-6.50%11.61K$25.34M$3.61 - $23.000.00%
4555NextTrip, Inc.NTRP$1.10-4.43%11.85K$16.74M$0.90 - $4.800.00%
4556Heron Therapeutics, Inc.HRTX$0.27-9.31%760.17K$51.26M$0.26 - $1.570.00%
4557Dermata Therapeutics, Inc.DRMA$0.77-9.29%32.23K$3.82M$0.60 - $4.660.00%
4558AETHLON MEDICAL INC.AEMD$5.48-4.20%7.79K$3.90M$1.41 - $25.660.00%
4559Alight, Inc.ALIT$12.14-6.82%421.29K$320.71M$7.93 - $57.000.16%
4560Solid Power, Inc.SLDP$2.06-7.56%3.08M$468.91M$1.91 - $8.860.00%
4561Lexaria Bioscience Corp.LEXX$3.91-3.93%19.28K$8.24M$2.43 - $21.600.00%
4562DNA X, Inc.SONM$2.79-2.33%25.44K$4.14M$2.21 - $11.900.00%
4563Aptera Motors Corp.SEV$2.02-2.40%107.79K$75.32M$1.29 - $8.800.00%
4564Jasper Therapeutics, Inc.JSPR$0.47-7.51%320.77K$15.61M$0.32 - $2.420.00%
4565APOLLO COMMERCIAL REAL ESTATE FINANCE, INC.ARI$2.38-4.78%1.67M$306.58M$2.28 - $11.240.49%
4566OBOOK Holdings Inc.OWLS$2.31+2.22%10.71K$203.17M$1.36 - $9.750.00%
4567Heartbeam, Inc.BEAT$0.40-6.30%368.74K$22.26M$0.35 - $4.000.00%
4568Foremost Clean Energy LtdFMST$0.67-9.12%118.64K$10.90M$0.42 - $3.490.00%
4569Bitdeer Technologies GroupBTDR$5.28-21.06%9.44M$1.44B$5.03 - $23.300.00%
4570Vivid Seats Inc.SEAT$2.85+1.32%14.97K$32.00M$2.03 - $12.720.00%
4571enCore Energy Corp.EU$0.63-11.84%1.69M$123.70M$0.63 - $3.670.00%
4572IREN LimitedIREN$18.18-16.77%62.72M$7.36B$17.18 - $76.870.00%
4573BitGo Holdings, Inc.BTGO$4.39-19.00%976.67K$603.01M$4.38 - $24.500.00%
4574Ambitions Enterprise Management Co. L.L.CAHMA$1.11+1.83%20.35K$31.81M$0.76 - $39.500.00%
4575QuantumScape CorporationQS$4.04-8.80%8.81M$2.38B$3.80 - $17.710.00%
4576Arbe Robotics Ltd.ARBE$0.41+1.02%836.05K$52.58M$0.39 - $1.940.00%
4577Investcorp Credit Management BDC, Inc.ICMB$0.65-4.28%9.71K$9.35M$0.62 - $3.120.43%
4578Circle8 Group, Inc.CIRC$0.19-14.05%230.90K$22.79M$0.19 - $0.980.00%
4579Quantum Biopharma LtdQNTM$2.11-5.88%46.24K$8.05M$2.05 - $12.420.00%
4580SS Innovations International Inc.SSII$1.73-23.35%106.21K$346.07M$1.64 - $7.760.00%
4581Cheche Group Inc.CCG$8.14+4.00%4.57K$16.08M$4.11 - $36.750.00%
4582BTQ Technologies Corp.BTQ$1.70-12.11%1.67M$253.86M$1.66 - $7.920.00%
4583ZeroStack Corp.ZSTK$2.74-0.90%15.77K$59.79M$1.32 - $15.040.00%
4584EUDA Health Holdings LimitedEUDA$14.78-1.00%12.19K$44.26M$5.26 - $71.200.00%
4585Filana Therapeutics, Inc.FLNA$0.48-12.59%385.21K$23.33M$0.48 - $2.270.00%
4586Tactical Resources Corp.TREO$1.65+2.04%13.34K$23.82M$1.40 - $9.200.00%
4587Genelux CorporationGNLX$1.79-8.16%151.33K$81.22M$1.75 - $8.540.00%
4588WEBUY GLOBAL LTDWBUY$0.52+0.40%21.27K$2.72M$0.49 - $4.960.00%
4589Pasqal Holding SAPSQL$4.36-13.99%477.37K$1.12B$4.33 - $24.690.00%
4590Exicure, Inc.XCUR$0.94+0.54%2.55K$6.12M$0.88 - $9.480.00%
4591Rocket One Inc.RKTO$0.39-12.91%219.88K$9.64M$0.39 - $2.450.00%
4592NervGen Pharma Corp.NGEN$1.35+1.85%184.69K$109.17M$1.28 - $6.300.00%
4593Atlas Critical Minerals CorporationATCX$2.00-4.95%4.93K$8.82M$1.85 - $14.010.00%
4594Cipher Digital Inc.CIFR$5.60-15.77%42.48M$2.32B$5.08 - $30.140.00%
4595Creative Medical Technology Holdings, Inc.CELZ$0.63-9.43%66.35K$4.18M$0.60 - $4.720.00%
4596Odyssey Marine Exploration, Inc.OMEX$11.04-2.52%20.63K$28.41M$9.59 - $66.750.00%
4597loanDepot, Inc.LDI$0.63-6.34%1.36M$145.51M$0.48 - $3.240.00%
4598Z Squared Inc.ZSQR$3.42-4.96%168.91K$181.00M$2.11 - $18.800.00%
4599Aclarion, Inc.ACON$1.69-2.71%6.55K$4.86M$1.69 - $9.360.00%
4600Nano Nuclear Energy Inc.NNE$9.75-11.60%2.11M$523.56M$9.31 - $45.460.00%

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Frequently Asked Questions (FAQ)

What are 52-week top gaining U.S. stocks?
These are U.S. stocks with some of the strongest price gains over the past 52 weeks, providing a view of longer-term stock performance.
How is the 52-week gain calculated?
It compares a stock's latest available price with its price roughly 52 weeks earlier and expresses the change as a percentage.
Which stock has gained the most over 52 weeks?
Gaxos.ai Inc. (GXAI) currently leads with a 52-week gain of 75.30% as of 2026-11-05 17:20 UTC.
Why use a 52-week stock performance ranking?
It helps users identify stocks with sustained price strength over a longer period rather than focusing only on daily market moves.
Does strong 52-week performance guarantee future gains?
No. Historical stock performance does not determine future returns and should be considered alongside company fundamentals and current market conditions.
How is this different from the daily Top Gainers list?
The 52-week ranking focuses on one-year performance, while Top Gainers highlights shorter-term price movements.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.