Buy Crypto
Markets
Spot
FuturesBTC
Earn
Event Center
Rewards Hub
More

52-Week Top Losing U.S. stocks

Track U.S. stocks with the largest price declines over the past 52 weeks on MEXC. Stocks are ranked by 52-week percentage change from lowest to highest.

52-Week Top Losing U.S. stocks

Market Overview

U.S. stocks are broadly lower today, with the Dow Jones down ⁦2.27%⁩, the S&P 500 down ⁦2.85%⁩, and the Nasdaq Composite down ⁦4.01%⁩. Market breadth is negative, with 4,173 stocks declining versus 942 advancing, pointing to a broadly bearish bias.

Dow Jones
52,145.9
Change
-1,210.22-2.27%
S&P 500
7,469.82
Change
-218.8-2.85%
Nasdaq Composite
24,704.101
Change
-1,032.412-4.01%
24H Gainers
942
24H Losers
4,173

52 Week Losers

#Stock52 Week Range
501Acurx Pharmaceuticals, Inc.ACXP$1.03-7.21%46.98K$5.73M$1.01 - $7.540.00%
502Defi Technologies, Inc.DEFT$0.35-8.84%269.38K$136.30M$0.34 - $1.790.00%
503ASP Isotopes Inc.ASPI$1.70-8.90%977.62K$259.86M$1.69 - $9.380.00%
504Capstone Energy Plus, Inc.CEPL$2.39-10.15%118.06K$84.01M$2.35 - $12.330.00%
505Alset Inc.AEI$0.55-2.33%630$21.24M$0.51 - $3.980.00%
506BOXABL, Inc.BXBL$1.99-2.55%41.09K$497.60M$1.89 - $11.990.00%
507Upland Software, Inc.UPLD$3.89-4.29%16.98K$11.49M$2.75 - $21.500.00%
508MacKenzie Realty Capital, Inc.MKZR$0.99-2.75%1.01K$2.75M$0.83 - $5.220.00%
509Maris-Tech Ltd.MTEK$0.30+14.31%581.06K$2.91M$0.21 - $2.820.00%
510Ainos, Inc.AIMD$0.66-8.64%6.52K$4.90M$0.56 - $3.880.00%
511Guardforce AI Co., LimitedGFAI$0.18-2.63%57.48K$5.91M$0.17 - $0.980.00%
512Neumora Therapeutics, Inc.NMRA$0.54-7.16%359.99K$100.90M$0.32 - $3.650.00%
513Pulsenmore Ltd.PLSM$1.51+0.93%2.80K$10.66M$1.48 - $12.970.00%
514Richtech Robotics Inc.RR$0.83-8.84%1.01M$153.32M$0.82 - $5.600.00%
515Globavend Holdings LimitedGVH$0.99+4.63%7.84K$4.28M$0.77 - $6.460.00%
516Expion Energy, Inc.XPON$3.09-7.76%10.66K$3.13M$2.77 - $19.200.00%
517CervoMed Inc.CRVO$1.52+0.32%68.03K$23.06M$1.46 - $10.000.00%
518Incannex Healthcare LimitedIXHL$2.35-0.40%9.91K$29.48M$2.17 - $14.910.00%
519Serve Robotics Inc.SERV$2.44-9.43%863.89K$211.13M$2.39 - $16.080.00%
520Eva Live Inc.GOAI$0.77-11.03%148.81K$31.36M$0.76 - $18.000.00%
521Haoxin Holdings LimitedHXHX$0.16-2.53%123.74K$1.57M$0.15 - $1.470.00%
522Xanadu Quantum Technologies LimitedXNDU$2.42-5.34%1.06M$791.42M$2.42 - $42.440.00%
523RenX Enterprises Corp.RENX$1.07-9.74%56.63K$3.73M$0.95 - $7.000.00%
524Avax One Technology LtdAVX$4.68+0.32%17.65K$34.61M$2.81 - $31.800.00%
525Enovix CorporationENVX$2.42-11.11%2.09M$529.97M$2.20 - $11.650.00%
526NeuroOne Medical Technologies CorporationNMTC$0.94-1.25%10.79K$8.54M$0.77 - $6.120.00%
527Tevogen Inc.TVGN$5.62-2.06%89$88.39M$3.64 - $32.500.00%
528DarioHealth Corp.DRIO$2.92-2.40%7.98K$28.66M$2.88 - $14.770.00%
529Intelligent Bio Solutions Inc.INBS$1.77+3.63%2.36K$5.88M$1.35 - $24.900.00%
530Rani Therapeutics Holdings, Inc.RANI$0.55-5.67%100.21K$62.91M$0.54 - $2.630.00%
531Sow Good Inc.SOWG$2.31+8.45%11.57K$46.43M$1.04 - $15.900.00%
532Swarmer, Inc.SWMR$6.77-11.13%223.78K$130.36M$6.76 - $83.300.00%
533Byrna Technologies, Inc.BYRN$4.03-3.95%48.63K$94.41M$3.17 - $20.690.00%
534First Breach Inc.FBDT$0.91-0.33%16.87K$52.44M$0.61 - $12.000.00%
535Processa Pharmaceuticals, Inc.PCSA$1.86-5.94%8.98K$5.20M$1.04 - $8.990.00%
536PowerCompute, Inc.PWCM$0.48-16.90%34.40K$1.22M$0.48 - $2.550.00%
537Organogenesis Holdings Inc.ORGO$0.87+2.30%34.84K$112.20M$0.73 - $7.080.00%
538Tilray Brands, Inc.TLRY$2.81-6.08%1.58M$416.02M$2.48 - $15.700.00%
539SharonAI Holdings, Inc.SHAZ$20.96-11.14%286.68K$747.48M$16.55 - $97.480.00%
540Alpha Compute Corp.ALP$3.09-3.71%8.83K$4.79M$2.78 - $27.900.00%
541Prairie Operating CoPROP$0.41+0.30%62.45K$45.80M$0.32 - $2.550.00%
542Reliance Global Group, Inc.EZRA$2.40-0.99%12.54K$4.03M$1.75 - $17.200.13%
543Australian Oilseeds Holdings LimitedCOOT$0.30+6.43%10.31K$8.31M$0.27 - $1.530.00%
544Nano Nuclear Energy Inc.NNE$9.76-10.68%636.61K$523.83M$9.67 - $45.460.00%
545NET Power Inc.NPWR$0.81-3.35%76.31K$71.49M$0.79 - $3.710.00%
546One and One Green Technologies. Inc.YDDL$1.03+1.47%6.10K$58.83M$0.91 - $16.230.00%
547Imunon, Inc.IMNN$0.90-3.44%7.67K$5.04M$0.81 - $4.380.00%
548Akebia Therapeutics, Inc.AKBA$0.48-31.03%4.72M$132.46M$0.47 - $2.130.00%
549Intensity Therapeutics, Inc.INTS$3.21+1.74%1.94K$10.50M$3.00 - $15.750.00%
550Fervo Energy CompanyFRVO$8.26-7.87%661.49K$2.43B$7.72 - $42.650.00%

Anthropic (PRE): Win NVIDIA H200

Claim PRE points for guaranteed prizes up to $3K

Anthropic (PRE): Win NVIDIA H200

Trade U.S. stocks Your Way on MEXC

RealStocksTokenized StocksStock Futures
What it isRealStocks — real shares of U.S.-listed companiesBlockchain-based tokens linked to U.S. stocks/ETFsUSDT-margined futures on U.S. stock price movements
OwnershipYes — actual sharesNo — synthetic exposure onlyNo — derivative exposure only
Shareholder rightsYes (e.g. dividends)NoNo
Trading hoursU.S. market sessions (pre-market, regular, after-hours, overnight)24/7Up to 24/7 (supported pairs)
Position typesBuy and holdBuy and holdLong, short, leveraged
Best forLong-term investors seeking ownership and dividend incomeTraders wanting round-the-clock access to stock exposure without holding sharesActive/short-term traders looking to speculate or hedge with leverage

Why Trade U.S. stocks on MEXC?

RealStocks, Real Ownership

Buy real US-listed shares through MEXC's partner licensed broker and receive applicable shareholder benefits, including dividends.

7,000+ U.S. stocks & ETFs

Access 7,000+ US-listed stocks and ETFs across technology, finance, healthcare, consumer sectors, and more.

Seamless USDT-to-Stock Access

Transfer USDT and convert between USDT and USD to fund your RealStocks account with ease.

Lower-Cost Stock Trading

Trade real U.S. stocks with competitive costs and keep more capital available for your investment strategy.

Frequently Asked Questions (FAQ)

What are 52-week top losing U.S. stocks?
These are U.S. stocks that have recorded some of the largest price declines over the past 52 weeks.
How is the 52-week decline measured?
It compares the latest available stock price with its price around 52 weeks earlier and calculates the percentage change.
Which stock has fallen the most over 52 weeks?
Acurx Pharmaceuticals, Inc. (ACXP) currently shows a 52-week decline of 80.00% as of 2026-11-05 16:55 UTC.
Why track 52-week stock losers?
The ranking helps identify stocks facing prolonged price weakness and provides a starting point for further company and valuation research.
Is a 52-week loser automatically a value stock?
No. A lower stock price does not necessarily mean a company is undervalued, so valuation and fundamental data should be reviewed separately.
How is this different from Top Losers?
52-Week Losers measures longer-term performance, while Top Losers focuses on shorter-term market declines.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.