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52-Week Top Gaining U.S. stocks

Track U.S. stocks with the strongest price gains over the past 52 weeks on MEXC. Stocks are ranked by their 52-week percentage change to highlight leading one-year performers.

52-Week Top Gaining U.S. stocks

Market Overview

U.S. stocks are broadly lower today, with the Dow Jones down ⁦2.13%⁩, the S&P 500 down ⁦2.73%⁩, and the Nasdaq Composite down ⁦3.83%⁩. Market breadth is negative, with 4,207 stocks declining versus 908 advancing, pointing to a broadly bearish bias.

Dow Jones
52,220.73
Change
-1,135.39-2.13%
S&P 500
7,479.01
Change
-209.61-2.73%
Nasdaq Composite
24,750.424
Change
-986.089-3.83%
24H Gainers
908
24H Losers
4,207

52 Week Gainers

#Stock52 Week Range
51Tango Therapeutics, Inc.TNGX$21.44-8.99%663.29K$3.62B$7.37 - $34.390.00%
52EuroDry LtdEDRY$36.41-4.94%67.58K$104.37M$12.11 - $73.070.00%
53RF Acquisition Corp IIRFAI$29.91+0.87%7.67K$105.05M$8.94 - $73.000.00%
54Glaukos CorporationGKOS$235.46-4.77%572.19K$13.94B$80.91 - $255.190.00%
55FIGS, Inc.FIGS$21.10-4.51%652.28K$3.33B$7.31 - $22.500.00%
56RINGCENTRAL, INC.RNG$75.71-3.60%511.07K$5.66B$24.14 - $98.140.00%
57Century Therapeutics, Inc.IPSC$1.54-8.38%172.99K$279.76M$0.43 - $3.040.00%
58Vestis CorporationVSTS$14.47-1.55%209.07K$1.91B$4.96 - $16.900.00%
59Quhuo LimitedQH$2.81+4.46%1.94K$8.25M$0.07 - $12.810.00%
60Maase Inc.MAAS$10.33-7.98%30.33K$4.50B$3.52 - $24.900.00%
61Prelude Therapeutics IncorporatedPRLD$3.74-9.56%69.21K$298.47M$1.17 - $6.830.00%
62Encore Capital Group, Inc.ECPG$114.53+13.07%176.05K$2.43B$41.10 - $120.170.00%
63Bandwidth Inc.BAND$39.24-13.49%304.99K$1.19B$12.50 - $79.080.00%
64Hinge Health, Inc.HNGE$120.52-0.90%424.78K$9.32B$30.08 - $124.940.00%
65Eton Pharmaceutcials, Inc.ETON$50.19-2.82%139.41K$1.43B$14.27 - $66.370.00%
66American Well CorporationAMWL$11.90-4.01%53.68K$179.30M$3.71 - $15.160.00%
67Relay Therapeutics, Inc.RLAY$16.89-6.82%1.02M$3.70B$5.95 - $21.270.00%
68American Outdoor Brands, Inc.AOUT$17.57-1.40%38.35K$221.69M$6.26 - $19.500.00%
69Okeanis Eco Tankers Corp.ECO$84.75-0.30%659.11K$3.56B$31.75 - $102.560.00%
70Lindblad Expeditions Holdings Inc.LIND$31.89-6.67%212.14K$2.09B$11.37 - $38.850.00%
71SharkNinja, Inc.SN$219.53-0.47%569.20K$30.93B$83.12 - $226.060.00%
72Absci CorporationABSI$9.66-10.21%1.73M$1.66B$2.24 - $12.540.00%
73Maravai LifeSciences Holdings, Inc.MRVI$7.26-8.03%1.04M$1.08B$2.54 - $9.420.00%
74Entravision CommunicationEVC$7.09-3.68%408.92K$588.43M$2.38 - $13.740.03%
75Haemonetics CorporationHAE$126.08-0.90%229.22K$5.74B$49.96 - $132.500.00%
76Omeros CorporationOMER$17.30-6.11%355.06K$1.25B$6.24 - $21.240.00%
77Septerna, Inc.SEPN$47.17-3.17%87.61K$2.02B$17.55 - $51.100.00%
78First Tracks Biotherapeutics, Inc.TRAX$45.83-7.37%174.24K$1.89B$14.72 - $50.170.00%
79Enliven Therapeutics, Inc.ELVN$45.51-4.57%426.73K$3.33B$14.79 - $62.320.00%
80Forum Energy Technologies, Inc.FET$71.22-3.27%50.03K$800.95M$28.00 - $91.990.00%
81Butterfly Network, Inc.BFLY$6.14-10.71%2.76M$1.51B$1.90 - $10.210.00%
82Dianthus Therapeutics, Inc.DNTH$82.34-5.30%264.62K$4.51B$32.42 - $117.880.00%
83Lifetime Brands, Inc.LCUT$7.49-14.74%130.76K$172.19M$2.90 - $10.170.02%
84Sezzle Inc.SEZL$161.00+16.05%1.20M$5.44B$49.50 - $195.710.00%
85Xencor, Inc.XNCR$34.82-1.60%424.45K$2.59B$10.38 - $36.090.00%
86Surrozen, Inc.SRZN$30.04-5.91%85.90K$348.74M$11.39 - $37.830.00%
87AbCellera Biologics Inc.ABCL$11.34-10.02%1.66M$3.48B$2.75 - $15.020.00%
88MMTec, Inc.MTC$5.34+4.91%1.92K$531.80M$0.31 - $9.100.00%
89QTREX Quantum Ltd.QTEX$0.94-9.80%2.59M$52.66M$0.28 - $3.850.00%
90InnovAge Holding Corp.INNV$9.57-1.12%116.45K$1.31B$3.94 - $12.640.00%
91LB Pharmaceuticals Inc.LBRX$38.81-6.00%113.34K$1.26B$14.32 - $50.160.00%
92Westrock Coffee CompanyWEST$10.20+0.10%205.63K$995.31M$3.59 - $10.570.00%
93Immix Biopharma, Inc.IMMX$7.30-9.41%366.58K$521.95M$2.85 - $15.100.00%
94Kiniksa Pharmaceuticals International, plcKNSA$92.40-3.77%214.11K$4.51B$37.02 - $98.480.00%
95Lumentum Holdings Inc.LITE$547.38-15.23%4.93M$49.58B$213.00 - $1,143.000.00%
96Iridium Communications Inc.IRDM$42.17-5.52%291.58K$4.48B$15.64 - $57.180.01%
97Biodesix, Inc.BDSX$20.12-7.68%55.35K$212.33M$5.26 - $31.970.00%
98CHATHAM LODGING TRUSTCLDT$15.13+0.87%128.68K$706.52M$6.08 - $15.590.04%
99GigaCloud Technology Inc.GCT$63.95+9.03%566.18K$1.84B$25.39 - $66.830.00%
100Lulu's Fashion Lounge Holdings, Inc.LVLU$10.54-0.93%4.50K$30.28M$4.37 - $32.320.00%

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Frequently Asked Questions (FAQ)

What are 52-week top gaining U.S. stocks?
These are U.S. stocks with some of the strongest price gains over the past 52 weeks, providing a view of longer-term stock performance.
How is the 52-week gain calculated?
It compares a stock's latest available price with its price roughly 52 weeks earlier and expresses the change as a percentage.
Which stock has gained the most over 52 weeks?
Tango Therapeutics, Inc. (TNGX) currently leads with a 52-week gain of 185.49% as of 2026-11-05 16:27 UTC.
Why use a 52-week stock performance ranking?
It helps users identify stocks with sustained price strength over a longer period rather than focusing only on daily market moves.
Does strong 52-week performance guarantee future gains?
No. Historical stock performance does not determine future returns and should be considered alongside company fundamentals and current market conditions.
How is this different from the daily Top Gainers list?
The 52-week ranking focuses on one-year performance, while Top Gainers highlights shorter-term price movements.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.